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Akkermansia muciniphila: The “Gatekeeper” of the Mucus Layer

Feb 03, 2026Next Microbiome

Akkermansia muciniphila is one of the most talked-about commensal bacteria in the context of cardiometabolic health over the last 10–15 years, known for its “mucus-loving” life strategy and residing in the intestinal mucus layer. In this article, we will address the species from its discovery to its genomic capacity, from molecular “cross-talk” mechanisms with the mucus barrier to clinical evidence, within a technical framework.

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